Extended Data Fig. 3: Ancestry principal components analysis of samples from the UK and Australian (principal components 2–5).
From: Common genetic variants contribute to risk of rare severe neurodevelopmental disorders
Reference samples (n = 2,504) from 1000 Genomes Phase 3—coloured by the five super-populations—are plotted on the left hand side, from projection PCAs with UK cohorts. Middle panels show the principal components plotted for DDD cases (discovery n = 10,556 and from trios n = 911) (UK samples) and Australian cases (n = 2,283). Red, case samples from individuals with European ancestry. Grey, samples from individuals of non-European ancestry; these individuals were excluded from analyses. Right-hand panels show principal components for UKHLS controls (n = 10,396) (UK samples) and Australian controls (n = 4,274). Blue, control samples from individuals with European ancestry. Grey, samples from individuals of non-European ancestry; these individuals were excluded from analyses. UK cohorts are plotted after removal of samples that failed quality control, and Australian cohorts before removal of samples that failed quality control.
