Extended Data Fig. 6: Nucleosomes show a synchronized shift in silent-gene promoters and heterochromatin regions, and show compressed spacing where they flank DHS centres.
From: Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing
a, Cartoon illustrates synchronized shift of adjacent nucleosomes within single nucleosome arrays. b, Bar plot showing synchronized shift score for different genomic regions. Silent promoter, silent-gene promoter; active promoter, active-gene promoter; not marked, regions not marked by any histone modifications as shown; DHS: ±2,000-bp region surrounding DHS centre; non-DHS, intervals of DHS regions. c, Synchronized shift score for nucleosome pairs with different distances of nucleosome space. d, Density plot of nucleosome-to-nucleosome distance in single cells reveals dominant nucleosome space at about 182 bp. e, Density plot of nucleosome spacing in the regions flanking strong and weak DHSs as well as non-DHSs. f, Distances between each pair of nucleosomes in the chromatin regions flanking strong DHS, weak DHS or non-DHS, described in e.
