Extended Data Fig. 10: In vitro killing studies.
From: Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys
a, GS-9620 treatment led to CD69 upregulation of CD56+ NK cells and CD3+ T cells in vitro following incubation of human PBMCs with 1,000 nM GS-9620 for 5 days (n = 9). b, GS-9620 treatment augmented PGT121-mediated killing of PGT121 in vitro. Per cent p24 reduction in CD4+ T cells (n = 6) using an antibody-mediated killing assay (see Methods). Per cent killing was calculated as the per cent reduction in p24 in CD4+ T cells with PGT121 compared with no PGT121. P values reflect two-sided paired Student’s t-tests.
