Extended Data Fig. 2: Crystal packing of the p300 core molecule.
From: Transcription factor dimerization activates the p300 acetyltransferase
a, There are four p300 molecules (monomers I–IV) in the asymmetric crystallographic unit. The four molecules show an antiparallel arrangement of the BRP-HAT domains. As a result, HAT domains from monomers I and II are closely apposed. Monomers III and IV engage monomer IVsym and monomer IIIsym, respectively, of a neighbouring crystallographic unit, showing that all promoters are in a AIL loop-swap conformation. Black arrows indicate the direction of the AIL. The disordered segment of the AIL is shown as a black dotted line. b, c, Electron density of the AIL. 2Fo − Fc (b) and Fo − Fc (c) difference density omit maps contoured at 0.8 and 2.0 r.m.s.d., respectively. Coloured as in Fig. 3.
