Extended Data Fig. 3: Structural analysis of the RING domains.
From: Transcription factor dimerization activates the p300 acetyltransferase
a, Superposition of the four p300 molecules (monomers I–IV) in the asymmetric crystallographic unit. Whereas the bromodomains (Bd), PHD and HAT domains superpose with a r.m.s.d. of approximately 0.9 Å, the RING domains adopt multiple conformations. b, 2Fo − Fc (blue mesh) and anomalous difference Fourier maps (orange mesh) for the four RING domains contoured around 1σ and 2.5σ, respectively.
