Extended Data Fig. 7: Integration of genetic events with drug sensitivity.
From: Functional genomic landscape of acute myeloid leukaemia
a, Circos plot showing AML rearrangements in the centre, mutational events in the next concentric ring, and gene expression events in the outer ring. The size and width indicates frequency of the event and the FDR-corrected Q value of association with drug sensitivity is colour-coded (sensitivity (red); resistance (blue)). For each gene, tests involving expression were two-sided Student’s t-tests (linear model) of the differences between sensitive and resistant samples. For mutational events, the average difference in AUC between mutant and wild-type samples was determined using two-sided Student’s t-tests from a linear model as shown in Fig. 2a. FDR was computed using the Benjamini–Hochberg method over all the drugs. The number of samples used to correlate each mutational event with drug sensitivity is reported in Supplementary Table 17. b, As in Fig. 2a, the average difference in AUC drug response between mutant and wild-type cases was determined using a two-sided Student’s t-test from a linear model fit (plotted on the x axis and the FDR-corrected Q value is plotted on the y axis). This analysis shows only FLT3-ITD-negative cases. FDR was computed using the Benjamini–Hochberg method over all the drugs. The number of samples used to correlate each mutational event with drug sensitivity is reported in Supplementary Table 17. Expanded and interactive plots are available in our online data browser (http://www.vizome.org/ and http://vizome.org/additional_figures_BeatAML.html).
