Extended Data Fig. 8: Integration of drug sensitivity with genetic events.
From: Functional genomic landscape of acute myeloid leukaemia
Correlation between drug sensitivity and mutational events. The average difference in AUC drug response between mutant and wild-type cases was determined using a two-sided Student’s t-test from a linear model fit. FDR was computed using the Benjamini–Hochberg method over all the drugs. The degree of significance is represented on the y axis (sensitivity (red); resistance (blue)). The number of samples used to correlate each mutational event with drug sensitivity is reported in Supplementary Table 17.
