Extended Data Fig. 3: Functional drug sensitivity landscape of the Beat AML cohort.
From: Functional genomic landscape of acute myeloid leukaemia
In total, 409 specimens from 363 patients with AML were subjected to an ex vivo drug sensitivity assay, in which freshly isolated mononuclear cells from blood or bone marrow of patient specimens were incubated with graded concentrations of 122 small-molecule inhibitors (seven dose points in addition to the no drug control). Probit curve fits were used to compute drug-response metrics, and the z score of area under the dose–response curve is plotted for each individual patient specimen against each drug. Drug sensitivity (blue) and resistance (red) are annotated by a colour gradient, with grey indicating no drug data available. The heat map is annotated at the top and bottom with major clinical, cytogenetic and genetic features of disease as indicated in the key.
