Extended Data Fig. 5: Pairwise drug sensitivity correlations and association with drug family.
From: Functional genomic landscape of acute myeloid leukaemia
To understand patterns of small-molecule sensitivity against prior annotations of the gene and pathway targets of each drug, drugs were placed into drug families according to target genes and/or pathways and the Pearson’s correlation value of each drug was plotted onto a clustered heat map, showing drugs with similar or dissimilar patterns of sensitivity across the patient cohort. Annotations based on prior knowledge of the drug families to which each drug could be assigned are shown to the right of the heat map with alternating black and grey boxes and labels used to aid in tracking. Descriptions of each drug family as well as the number of samples used to calculate each pairwise drug correlation are found in Supplementary Tables 11, 21.
