Extended Data Fig. 6: Cell-to-cell variability versus response divergence across species and conditions in mononuclear phagocytes after LPS stimulation.
From: Gene expression variability across cells and species shapes innate immunity
Cell-to-cell variability values, as measured with DM across cells, compared with response divergence between species (grouped into low, medium and high divergence). Variability values are based on n = 3,519, 4,321, 3,293, 2,126 mouse cells, n = 2,266, 2,839, 1,963, 1,607 rat cells, n = 3,275, 1,820, 1,522, 1,660 rabbit cells, and n = 1,748, 1,614, 1,899, 1,381 pig cells, stimulated with LPS for 0, 2, 4 and 6 h, respectively. Rows represent different LPS stimulation time points (0, 2, 4 and 6 h), and columns represent different species as shown. High-divergence genes were compared with low-divergence genes using a one-sided Mann–Whitney test. Data in boxplots represent the median, first quartile and third quartile with lines extending to the furthest value within 1.5 of the IQR.
