Extended Data Fig. 9: Cell-to-cell variability levels in cytokines, transcription factors and kinases across species and stimulation time points.
From: Gene expression variability across cells and species shapes innate immunity
Violin plots showing the distribution of cell-to-cell variability values (DM) of cytokines, transcription factors and kinases during immune stimulation. Left, fibroblast dsRNA stimulation time course. Number of cells used in each species (at 2, 4, 8 h dsRNA, respectively): human, 56, 55, 35; macaque, 32, 29, 13; rat, 70, 65, 40; mouse, 81, 59, 30. Right, phagocyte LPS stimulation time course. Number of cells used in each species (at 2, 4, 6 h LPS, respectively): mouse, 4,321, 3,293, 2,126; rat, 2,839, 1,963, 1,607; rabbit, 1,820, 1,522, 1,660; pig, 1,614, 1,899, 1,381. For both panels, colours as in Fig. 3c. Comparisons between groups of genes were performed using one-sided Mann–Whitney tests. Violin plots show the kernel probability density of the data.
