Extended Data Fig. 3: Comparison of response divergence of genes containing various promoter elements.
From: Gene expression variability across cells and species shapes innate immunity
Comparison of response divergence between genes with and without a TATA-box and a CGI. Left, fibroblasts (n = 14, 14, 633 and 294 differentially expressed genes with only TATA-box element, with both CGI and TATA-box elements, with only CGI, and with neither element in their promoters, respectively); right, phagocytes (n = 13, 29, 1,718 and 576 differentially expressed genes with only a TATA-box element, with both CGI and TATA-box elements, with only a CGI, and with neither element in their promoters, respectively). Genes with a TATA-box without a CGI have higher response divergence than genes with both elements. Genes with a CGI but without a TATA-box diverge more slowly than genes with both elements. Genes with both elements do not differ significantly in their divergence from genes lacking both elements (one-sided Mann–Whitney test). Data in boxplots represent the median, first quartile and third quartile with lines extending to the furthest value within 1.5 of the IQR.
