Extended Data Fig. 5: Cell-to-cell variability versus response divergence across species and conditions in fibroblasts after dsRNA stimulation.
From: Gene expression variability across cells and species shapes innate immunity
Cell-to-cell variability values, as measured with DM across individual cells, compared with response divergence between species (grouped into low, medium and high divergence). Variability values are based on n = 29, 56, 55, 35 human cells, n = 20, 32, 29, 13 rhesus cells, n = 33, 70, 65, 40 rat cells, and n = 53, 81, 59, 30 mouse cells, stimulated with dsRNA for 0, 2, 4 and 8 h, respectively. Rows represent different dsRNA stimulation time points (0, 2, 4 and 8 h), and columns represent different species as shown. High-divergence genes were compared with low-divergence genes using a one-sided Mann–Whitney test. Data in boxplots represent the median, first quartile and third quartile with lines extending to the furthest value within 1.5 of the IQR.
