Extended Data Fig. 5: Inter-subunit interaction at the ECD–TMD–ICD interface.
From: Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor
a, Inter-subunit interactions at the ECD–TMD interface in the apo state, state 1 and state 2. b, Inter-subunit interactions at the TMD–ICD interface in the three states. The potential interactions were predicted as polar contacts in PyMOL. Interacting residues are shown as sticks. Residue labels are colour-coded based on their location. The apo state has the largest buried surface area (31,610 Å2) which progressively decreases in state 1 (30,960 Å2) and then state 2 (25,340 Å2).
