Extended Data Fig. 4: Fit of the models to the densities.
From: Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states
a, Fit of the TM helices of the final model of the ABCG2EQ–E1S TMD to the post-processed and masked C2 map from CryoSPARC. A region of up to 2 Å around the atoms is shown. b, The fit of one E1S molecule (pink or turquoise sticks) in two possible orientations, flipped by 180°, docked into the C2-symmetrized substrate density of the final model of ABCG2EQ–E1S. The contour level has been reduced by comparison with Fig. 2a to show the strongest density at the core of the polycyclic rings. c, As for b, but showing the fit of one E1S into the electron microscopy density of the post-processed and masked C1 map from CryoSPARC. d, Fit of the TM helices of the final model of the ABCG2EQ–ATP TMD to the post-processed and masked C2 map from RELION. A region of up to 2 Å around the atoms is shown.
