Extended Data Fig. 6: Substrate densities in different states.
From: Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
a, Close-up views of two typical substrate densities observed in the CP chamber in state EA. Left, the substrate density directly contacting the proteolytically active Thr1 in subunit β2. Right, a long substrate density at the seam between two β4 subunits inside the CP. b, The overall ATPase ring density of state EB (left) and a close-up view of the substrate density (right). c, The overall ATPase ring density of states EC1,2 (left) and a close-up view of the substrate density (right). d, The overall ATPase ring density of states ED1,2 (left) and a close-up view of the substrate density (right). All close-up views were directly screen-copied from Coot56 after atomic modelling into the density maps without modification.
