Extended Data Fig. 3: LTP at hippocampus–NAc synapses is not associated with preferential insertion of GluA2-lacking AMPA receptors.
From: Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses
a, Wash-in of NASPM after LTP induction does not alter EPSC amplitude. Centre values represent mean and error bars represent s.e.m. b, Summary data from the last 5 min of recording. Two-tailed Mann–Whitney U-test: U = 24, P > 0.9999, n = 7, 7 mice; two-tailed paired t-test baseline EPSC amplitude/30 min post HFS: control: t = 2.508, P = 0.046, n = 7 cells; NASPM: t = 2.747, P = 0.0226, n = 10 cells. c, HFS does not alter rectification at positive holding potentials. Two-tailed Mann–Whitney U-test: U = 12, P = 0.7879, n = 7, 4 mice. Centre values represent mean and error bars represent s.e.m. #Significant increase in EPSC amplitude above baseline revealed by paired t-test. For box plots, the line in the middle of the box is plotted at the median. The box extends from the 25th to the 75th percentiles. Whiskers represent minimum and maximum.
