Extended Data Fig. 4: D1 receptor signalling is required for LTP induction at non-specific NAc synapses.
From: Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses
a, Pre-incubation with D1 receptor antagonist SCH23390 blocks LTP induction in response to HFS. b, Summary data from the last 5 min of recording. Two-tailed Mann–Whitney U-test: U = 2, P = 0.0317, n = 5 mice per group. #Two-tailed paired t-test baseline EPSC amplitude/30 min post HFS: control: t = 3.017, P = 0.0393, n = 5 cells; SCH: t = 0.5016, P = 0.6372, n = 6 cells. LTP kinetic data are plotted in 1-min bins. Centre values represent mean and error bars represent s.e.m. For box plots, the line in the middle of the box is plotted at the median. The box extends from the 25th to 75th percentiles. Whiskers represent minimum and maximum.
