Extended Data Fig. 5: D2 receptors are not required for LTP induction.
From: Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses
a, Pre-incubation with the D2-receptor antagonist sulpiride does not affect the ability to elicit LTP in response to HFS in D2R-MSNs. b, Summary data from the last 5 min of recording. Two-tailed Mann–Whitney U-test: U = 20, P = 0.9452, n = 6, 7 mice. #Two-tailed paired t-test baseline EPSC amplitude/30 min post HFS: control: t = 3.840, P = 0.0121, n = 6 cells; sulpiride: t = 4.246, P = 0.0022, n = 10 cells. c, Representative traces of EPSCs from control and sulpiride-treated D2R-MSNs. #Significant increase in EPSC amplitude above baseline revealed by paired t-test. LTP kinetic data are plotted in 1-min bins. Centre values represent mean and error bars represent s.e.m. For box plots, the line in the middle of the box is plotted at the median. The box extends from the 25th to 75th percentiles. Whiskers represent minimum and maximum. Scale bar for representative traces, 10 pA/10 ms.
