Extended Data Fig. 3: Stella prevents UHRF1-dependent aberrant DNA methylation during oogenesis.
From: Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1
a, DNA methylation level in sperm from Stella+/− and Stella−/− mice. The cumulative bar plot shows the proportions of 100-bp tiles in four methylation level ranges. b, c, Average DNA methylation levels of different genomic contexts (b) and repeat elements (c) in MII oocytes. d, Genome browser views of DNA methylation in the HoxA, HoxB, HoxC and HoxD cluster regions of the genome. e, DNA methylation of CpG islands in MII oocytes and sperm from Stella+/− and Stella−/− mice. The cumulative bar plot shows the proportions of 100-bp tiles in five methylation level ranges. f, Genome browser views of DNA methylation in the DMRs of the maternally imprinted genes Zac1 (also known as Plagl1) and Impact. g, Bisulfite sequencing analysis of the DMRs of the paternally imprinted genes H19 and Rasgrf1 in D20 growing oocytes. The data shown are representative of two independent experiments.
