Extended Data Fig. 4: Gene expression in B. schlosseri cell populations.
From: Complex mammalian-like haematopoietic system found in a colonial chordate
a, Enrichment scores of the top nine systems (left), nine tissues (centre) and ten cell types (right) of annotated genes upregulated in CP33, CP34 and CP25 using the GeneAnalytics tool (compared to human). In systems the haematopoietic system has the highest score, in tissues the blood has the highest score, and within the cells, the granulocytes and HSC have the highest scores. b–d, Geneset Activity Analyses using the Gene Expression Commons tool on a mouse haematopoiesis model of different B. schlosseri cell populations. b, Analysis of CP8 (pigment cells) based on 12 significantly upregulated genes, showing that CP8 is part of the haematopoietic system with gene activity resembling known cell types. c, Analysis of CP3 (small cells) based on 235 significantly upregulated genes, showing that this population is not part of the haematopoietic system. On the bottom: enrichment scores of the top ten tissues using CP3 genes by GeneAnalytics tool compared to human; the highest score is for the testes, suggesting that this population is a gonadal population. d, Analysis of CP19 (enriched with morula cells) based on 96 upregulated genes (P < 0.25), showing that CP19 has gene activity resembling cells in the lymphoid lineage using Geneset analysis.
