Extended Data Fig. 1: Previously known structures of CCR5 and CXCR4.
From: Structural basis of coreceptor recognition by HIV-1 envelope spike
CCR5 and CXCR4 were identified as the coreceptors for HIV-1 entry in 199671,72,73,74,75,76,77. a, b, Crystal structures of a modified CCR5 (C224–N226 deleted and replaced with rubredoxin; ΔF320–L352; and the point mutations C58Y, G163N, A233D and K303E) in complex with the HIV entry-inhibitor maraviroc (PDB ID: 4MBS7) (a) and a modified chemokine [5P7]CCL5 (an antagonist; PDB ID: 5UIW10) (b). CCR5 is shown in ribbon diagram in blue, with the internally fused rubredoxin in magenta and the ligands in yellow. c–e, Crystal structures of an engineered CXCR4 in complex with a viral chemokine antagonist vMIP-II (PDB ID: 4RWS15) (c), a small molecule antagonist IT1t (PDB ID: 3ODU14) (d) and a cyclic peptide antagonist CVX15 (PDB ID: 3OE014) (e). CXCR4 is shown in green, the fused T4 lysozyme in magenta and the ligands in yellow.
