Extended Data Fig. 5: Single-particle cryo-EM analysis of the CD4–gp120–CCR5 complex.
From: Structural basis of coreceptor recognition by HIV-1 envelope spike
a, Data-processing workflow for the CD4–gp120–CCR5 complex. b, 3D reconstructions of the CD4–gp120–CCR5 complex refined with no mask at an overall resolution of 4.5 Å (left), and with a mask to exclude the last two domains of CD4 at a resolution of 3.9 Å (right), are coloured according to local resolution estimated by RELION. c, The angular distribution of the cryo-EM particles used in the reconstruction is also shown in respect to both the side and top views of the electron microscopy map. d, Gold standard Fourier shell correlation curves of the unmasked and masked electron microscopy reconstructions shown in b.
