Extended Data Fig. 8: Spatial architecture of clones in representative PNE biopsies.
From: Age-related remodelling of oesophageal epithelia by mutated cancer drivers
a, Mutation analysis of 341 samples obtained by high-density sampling from 16 biopsy specimens from 14 individuals with different age, lifestyle ESCC risks, and ESCC status (bottom panels), using WES (249 from 10 biopsies) or targeted-capture sequencing of major drivers (92 from 6 biopsies). Total numbers of mutations (top) are depicted for samples analysed by WES. Shared mutations are shown in orange. Mutation status of major drivers and common CNAs are summarized (middle panels). b–e, MCFs of detected mutations are depicted for each sample obtained by high-density collection from PNE biopsies performed on low-risk healthy individuals in their 20s (b–d) and an 81-year-old, low-risk man (e). Four representative examples from 10 biopsies analysed by high-density WES sampling are shown. Mutations shared by a distinct set of samples or isolated samples are integrated to identify unique clones, as shown in different colours. Driver mutations are indicated by downward-pointing arrowheads. Rightward-pointing arrows indicate the clones in the same colour in Fig. 4b, c and Extended Data Fig. 9a, b.
