Extended Data Fig. 3: Somatic mutations in solitary sampling.
From: Age-related remodelling of oesophageal epithelia by mutated cancer drivers
a, Summary of somatic mutations found in 157 PNE, 12 dysplasia and 20 cancer samples from individuals with (pink) or without (green) lifestyle ESCC risks. MCFs are plotted for all mutations (upper panel). Driver mutations are shown by coloured triangles as indicated. Information about histology and sample size is shown on the top lanes. The age of the subject and the total number of mutations are shown in the bottom panels. Status of ESCC, CNAs and mutations are also shown (middle panels). b–j, MCFs of somatic mutations detected in WES of multiple samples from PNE, as well as dysplastic and cancer tissues, are depicted separately for shared (orange) and non-shared mutations (grey) in representative cases from 16 independent individuals, for whom multi-regional sampling was performed. Mutations in TP53, NOTCH1, PPM1D and other drivers are indicated by arrowheads in different colours. Positions of tumours and biopsy samples are shown on the left in each panel. Distance from the maxillary dental arch is indicated. Mutations are shared only between cancer samples except in two cases (i and j), in which small numbers of mutations (between 3 and 16) are shared between mutually positioned samples as indicated.
