Extended Data Fig. 5: Modelling of the highest possible turnover during the disease period that could occur undetected with carbon dating.
From: Dynamics of oligodendrocyte generation in multiple sclerosis
Different annual turnover rates during the disease period were modelled to find the highest possible turnover rate that could occur undetected. It was assumed that there was a healthy turnover before disease onset. If a comparison between the measured 14C and the modelled values is significant, we would be able to detect that turnover rate. The lowest turnover rate with significant difference tested was 0.1% annual turnover (P = 0.041, two-tailed Mann–Whitney U-test, n = 6). At 0.05% annual turnover, there was no longer a significant difference (P = 0.132, two-tailed Mann–Whitney U-test, n = 6). Data are mean (long line), ± s.d. (short lines).
