Extended Data Fig. 2: Bacteria from the healthy human gut microbiota associated with IFNγ+ CD8 T cell induction.
From: A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
a, Schematic representation of the strategy for isolating IFNγ+ CD8 T cell-inducing bacteria from the healthy human gut microbiota. b, Representative flow cytometry plots showing the expression of IFNγ and CD8α by colonic or small intestinal lamina propria CD3+TCRβ+ T cells from germ-free mice orally inoculated with healthy human faecal samples (from donors A to F). c, Spearman’s correlation coefficient and P values for the relationship between the number of individual bacterial 228 OTUs (among 3,000 reads) detected in mice shown in Fig. 1e and the percentage of colonic IFNγ+ CD8 T cell population shown in Fig. 1d was calculated using GraphPad Prism. OTUs positively and negatively correlated with the frequency of colonic IFNγ+ CD8 T cells with statistical significance (P < 0.05) are highlighted in red and dark blue, respectively. OTUs detected in GF+CHL B5 mice are marked in light and dark blue. OTUs showing no significant correlation (P > 0.05) are marked in grey. The closest species/strain and individual Rho (ρ) value for each OTU are shown.
