Extended Data Fig. 5: Agreement between the cryo-EM map and the model.
From: Structural insights into the activation of metabotropic glutamate receptors
a–h, Representative cryo-EM densities and fitted atomic models for apo (a, b) and active (c–h) mGlu5. The B and C helices of the VFT and the 7TM domain are highlighted in a for the apo mGlu5 structure, and density and model fits are shown in b. Various helices of the VFT, as well as the ligand-binding pocket, CRD and TM6 are highlighted in c, and their cryo-EM density and fitted models are shown in d–h for active mGlu5 bound to Nb43 and l-quisqualate.
