Extended Data Fig. 6: Comparison of the intersubunit interfaces in apo and active mGlu5.
From: Structural insights into the activation of metabotropic glutamate receptors

Comparison of intersubunit interfaces in apo and active mGlu5 are shown for apo (top) and active (bottom) mGlu5. Contact regions (purple) show residues within 4 Ă… of the opposite subunit. Notably, apo mGlu5 lacks any interactions beyond the VFT.