Extended Data Fig. 7: Comparison of cryo-EM structures of full-length mGlu5 with crystal structures.
From: Structural insights into the activation of metabotropic glutamate receptors
a, The conformation of the VFT and CRD portions of full-length apo mGlu5 obtained using cryo-EM (coloured cartoon) is almost identical to the conformation revealed by the crystal structure of the full-length apo mGlu5 (7TM domain not resolved; grey cartoon). b, Similarly to the apo-state structures, the conformation of the VFT and CRD portions of full-length Nb43-bound, active-state mGlu5 obtained by cryo-EM (coloured cartoon) is almost identical to the conformation revealed by the crystal structure of the ECD bound to l-quisqualate and Nb43. c, d, Despite being bound to a NAM (green) and a PAM (blue), the 7TM domains of in our full-length structures both align almost identically to a crystal structure of a NAM-bound 7TM domain in isolation (c) as well as to each other (d).
