Extended Data Fig. 8: Molecular dynamics simulations of mGlu5 ECD-Nb43.
From: Structural insights into the activation of metabotropic glutamate receptors
Simulation of the apo form of mGlu5 ECD both with and without Nb43. In the absence of Nb43, the ECD relaxes to an open conformation (right) with considerable separation between the bottom lobes of the VFT. The presence of Nb43 restricts opening of the ECD to an intermediate degree (middle) but does not stabilize the compact resting state (left).
