Extended Data Fig. 7: P28 and P56 modulation of pyramidal cell somas and dendrites during spontaneous activity.
From: Neuromodulatory control of localized dendritic spiking in critical period cortex
a, Plot of the visually evoked median ΔF/F of each cell as a function of behavioural state, for all recorded cells, at P28 and P56, in the absence of visual stimulation, measured at the soma (P28: n = 563 cells; P56: n = 723 cells). Still to run, P = 4.31 × 10−60 (P28), P = 1.94 × 10−89 (P56), Wilcoxon signed-rank test. b, Plot of cumulative distributions of the correlation coefficients of GCaMP6f signals to running for all recorded pyramidal neurons while viewing a grey screen (P28: n = 860 cells; P56: n = 513 cells). P = 0.993, Mann–Whitney U-test. c, Box plots of temporally deconvolved event probabilities of dendrites during grey screen viewing at P28 and P58 during in running and still conditions (P28: n = 36 branches; P56: n = 96 branches). Still to run, **P = 0.0044 (P28), ***P = 4.36 × 10−6 (P56), Wilcoxon signed-rank test. d, Box plots of the fold change between sister branches as a function of age and behavioural state (P28: n = 18 branch pairs; P56: n = 56 branch pairs). Still to run, P = 0.987 (P28), P = 0.02 (P56), Wilcoxon signed-rank test. e, Box plots of the correlation coefficients between event probability time series of sister branches as a function of age and behavioural state (P28: n = 18 branch pairs; P56: n = 56 branch pairs). Still to run, P = 0.2914 (P28), **P = 0.0042 (P56), Wilcoxon signed-rank test. Box plot parameters as in Fig. 1.
