Extended Data Fig. 9: Verification of chemogenetic control of SST cells using DREADDs.
From: Neuromodulatory control of localized dendritic spiking in critical period cortex
a, Top, example evoked responses of a SST cell expressing DREADD receptors. Bottom, evoked responses from the same SST cell 4 h after intraperitoneal administration of CNO (2.5 mg kg−1). Scale bar, 10% ΔF/F and 30 s. b, Measurement of change in median evoked ΔF/F in SST cells after CNO administration over an 8 h period, in mice with or without DREADD expression (DREADD−/CNO+: n = 25 cells; DREADD+/CNO+: n = 21 cells). 2 h, DREADD− to DREADD+: ***P = 1.41 × 10−4; 4 h, DREADD− to DREADD+: ***P = 7.98 × 10−5, Wilcoxon signed-rank test. Error bars denote s.e.m.
