Extended Data Fig. 3: VIP cells show no age-dependent changes in cholinergic modulation.
From: Neuromodulatory control of localized dendritic spiking in critical period cortex
a, As in Fig. 1, example VIP cell populations from P28 and P56. b, Plot of the visually evoked median ΔF/F of each cell as a function of behavioural state, for all recorded cells (P28: n = 220; P56: n = 305). Still to run, P = 1.63 × 10−64 (P28), P = 1.75 × 10−60 (P56), Wilcoxon signed-rank test. c, Example traces of VIP cell response to CCh application at P28 (left) and P56 (right). Recordings were made under current clamp and in the presence of synaptic blockers. Coloured box denotes time of CCh application. Insets show evoked VIP cell waveform. Scale bars, 0.25 s and 10 mV. d, Box plot of VIP cell firing rates evoked by CCh as a function of age (P28: n = 10; P56: n = 8). P = 0.9804, Mann–Whitney U-test. Box plot parameters as in Fig. 1.
