Extended Data Fig. 4: Local density maps of the Snf2–nucleosome complex in the ADP-BeFx-bound state.
From: Mechanism of DNA translocation underlying chromatin remodelling by Snf2
a, b, Density maps of the nucleosome with ADP-BeFx-bound Snf2 at SHL2 (a) and SHL−2 (b). The boxed regions are enlarged for further analyses on the right. c, Comparison of the structures of the SHL2 (colour-coded) and SHL−2 (grey) complexes. Structures of the nucleosome are shown on the right. d, Density map of Snf2 in the ADP-BeFx-bound state. The brace-II and post-HSA (helicase-SANT-associated) helices show weak cryo-EM density. e, Density map of the catalytic pocket of Snf2 in the ADP-BeFx-bound state. BeFx is modelled by a BeF3 molecule (magenta). f, Structural comparison of the ATP-binding pocket of Snf2 (colour-coded) and NS3 helicase (grey, PDB code 3KQU40). g–j, Local density maps near Arg1142 (g), Arg1164 and Trp1185 (h), α13/Thr1113 (i), and motif II centring on Lys900 (j).
