Extended Data Fig. 2: Validation of TMB ≤ 10 as an analysis threshold.
From: The expanding landscape of ‘oncohistone’ mutations in human cancers
a, For known oncohistones, the number of mutations captured reaches a plateau at a TMB of greater than 10 mutations per Mb. b, c, Histogram plot of H3 mutation distribution on a per patient level without a TMB threshold (b) and with a TMB ≤ 10 threshold (c) shows enrichment of known oncohistones as well as additional mutations compared to background.
