Extended Data Fig. 9: T cell cooperativity and antigen density determine CAR T cell killing capacity.
From: CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape
Tumour lysis frequency in wells containing a ratio of one CAR T cell:one tumour cell (R1:1 E:T) and one CAR T cell:two tumour cells (R2:1 E:T). a, c, d, NALM6 cells (a), NALM6med cells (c) and NALM6low cells (d). b, Estimated and observed killing percentage in wells containing one CAR T cell and two NALM6 cells (R2:1 E:T). Estimated percentage of killing is calculated as described in the Methods. P values were determined by two-sided two-sample test of proportions (a, c and d) and one-sided two-sample test of proportions (b), n = 5 donors (a), and n = 3 donors (c, d). In b, P < 0.1 is used as significance level (n = 5 donors). Data are mean ± s.e.m. Primary data in this figure are presented in Fig. 3.
