Extended Data Fig. 2: Leukaemic response and relapse patterns associated with SJ25C1 and FMC63 scFv-based CARs.
From: CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape
a, Schematic representation of the CD19 CARs using the scFv SJ25C1 or FMC63. b, c, Kaplan–Meier survival analysis of mice bearing NALM6 cells treated with 0.2 × 106 transduced CAR T cells. n = 5–7 mice per group pooled from two independent experiments. (One of the groups shown in b is one of two experiments merged in Fig. 1a.) d, Representative FACS profile of cells isolated by the time of relapse (data are representative of n = 3 mice per group). e, f, Representative FACS profile of surface CD19 expression on NALM6 cells isolated by the time of relapse (data are representative of n = 3 mice per group). e, Mice treated with SJ25C1-28ζ or FMC63-28ζ. f, Mice treated with SJ25C1-BBζ or FMC63-BBζ. g, Representative FACS profile of PD-1, LAG-3 and TIM-3 surface expression on BBζ CAR T cells isolated from relapsed mice (data are representative of n = 3 mice per group). P values were determined by log-rank Mantel–Cox test (b, c).
