Extended Data Fig. 4: Trogocytosis occurs with several targets and cell types.
From: CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape
a, Top, MFI of CD19 on the cell surface of NALM6, SUP-B15, Raji and SK-OV-3-CD19+ cells co-cultured with 19-BBζ CAR T cells. Bottom, MFI of CD19 on CAR T cell surface (n = 3 donors). b, MFI of CD19 on NALM6 cells co-cultured with 19-28ζ CAR T cells from patients with ALL and CLL (n = 4 patient samples). c, MFI of CD22 on NALM6 cell surface (top) and CD22 CAR T cells (bottom). BCMA CAR T cells are used as control. d, MFI of BCMA on KMS-12-BM cell surface (top) and BCMA CAR T cells (bottom). CD22 CAR T cells are used as a control. e, MFI of MSLN on A549 MSLN+ cell surface (top) and MSLN CAR T cells (bottom). CD19 CAR T cells are used as a control. In c–e, n = 3 independent samples, and data are representative of three donors. Data are mean ± s.e.m.
