Extended Data Fig. 5: Therapeutic response and relapse patterns after CD22 CAR T cell treatment.
From: CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape
a, Tumour burden was monitored using bioluminescence imaging (average radiance (photons s−1 cm−2 sr−1)) in mice bearing NALM6–GFP luciferase treated with 0.2 × 106 CAR T cells 4 days later (n = 7 mice per group). b, Absolute count of CAR T cells. c, Quantification of CD22 molecules on NALM6 cell surface. d, Expression of PD-1, LAG-3 and TIM-3 on CAR T cell surface. b–d, Cells were obtained from mice bone marrow at day 21 (relapse time, n = 5 mice per group). e, Quantification of CD22 molecules on NALM6 surface 6 days after ex vivo culture (CD22-28ζ and CD22-BBζ, n = 5 independent samples per group, NALM6, n = 3 independent samples) . NA, not available (no detectable cells). P values were determined by two-sided Mann–Whitney U-test. Data are mean ± s.e.m.
