Extended Data Fig. 2: The GCR is triggered in capn3a genetic mutants carrying a functional PTC.
From: PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components
a, Schematic diagram showing an additional five mutant alleles (mu2–mu6) of the zebrafish capn3a gene. Black line denotes intron; black bar denotes exon; red line denotes deletion or insertion of DNA in different capn3a mutant alleles. b–f, Left, relative mRNA expression of capn3a family members in wild-type and different capn3a mutant alleles at 3 dpf. Right, statistical analysis of the average liver sizes in wild-type and different capn3a mutant alleles at 3.5 dpf. Each experiment was repeated three times with similar results and a representative result is shown. n indicates the number of zebrafish embryos in each group. Data are mean ± s.d. from three biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001, two-tailed t-test.
