Extended Data Fig. 9: Paralogue dependencies and hypermutation alone cannot explain the WRN–MSI relationship.

a, Estimated association between WRN dependency and MSI status after controlling for loss of indicated genes (effect size estimates for the linear model are plotted against significance). If loss of a gene can fully account for the MSI–WRN relationship, the difference in dependency and significance would be 0. Genes for which the loss are typically associated with insertion and deletion (indel) mutations (over half of loss events) are highlighted in red. n = 51 MSI, n = 541 MSS. b, Average WRN dependency score for MSS and MSI lines stratified by POLE status (n = 4, 5, 35, 497, 2, 12, 5, 10, 22 cell lines per category in order of left to right). Boxes indicate 25th and 75th percentiles; whiskers extend to 1.5× IQR beyond the box and individual data points are represented by dots.