Extended Data Fig. 2: MSI cells from MSI-predominant lineages have a greater mutational burden and WRN dependency.
From: WRN helicase is a synthetic lethal target in microsatellite unstable cancers
a, WRN dependency scores plotted by lineage, sub-classified by MSI and MSS status. Boxes indicate 25th and 75th percentiles; whiskers extend to 1.5× IQR beyond the box and individual data points are represented by dots. b, Microsatellite deletions in cell lines classified as MSS (n = 541), MSI from an infrequent MSI lineage (n = 45), or MSI from an MSI-predominant lineage (n = 54). *P = 1.7 × 10−9, Wilcoxon signed-rank test. Width of coloured regions represent density estimates. c, MSI cell lines plotted by their average WRN dependency and number of microsatellite deletions. Lineages are colour-coded. d, MSI cell lines from MSI-predominant lineages are plotted by their average WRN dependency and number of microsatellite deletions. Lineages are colour-coded.
