Extended Data Fig. 2: Germline and haematopoietic cfDNA fragment distributions.
From: Genome-wide cell-free DNA fragmentation in patients with cancer
a, Cumulative density functions of fragment lengths at 44 loci containing germline alterations (non-tumour derived) from 38 patients with breast, colorectal, lung or ovarian cancer are shown with 95% confidence bands. Fragments with germline mutations (orange) were comparable in length to wild-type cfDNA fragment lengths (blue). b, Cumulative density functions of fragment lengths at 41 loci containing haematopoietic alterations (non-tumour derived) from 28 patients with breast, colorectal, lung or ovarian cancer are shown with 95% confidence bands. After correction for multiple testing, there were no significant differences (α = 0.05) in the size distributions of mutated haematopoietic cfDNA fragments (orange) and wild-type cfDNA fragments (blue).
