Extended Data Fig. 5: Profiles of cfDNA fragment lengths in copy neutral regions in healthy individuals and one patient with colorectal cancer.
From: Genome-wide cell-free DNA fragmentation in patients with cancer
a, The fragmentation profiles in 211 copy neutral windows in chromosomes 1–6 are shown for 25 randomly selected healthy individuals (grey). For a patient with colorectal cancer (CGCRC291) with an estimated mutant allele fraction of 20%, we diluted the cancer fragment length profile to an approximate 10% tumour contribution (blue). a, b, Although the marginal densities of the fragment profiles for the healthy samples and patient with cancer show substantial overlap (a, right), the fragmentation profiles are different as can be seen through visualization of the fragmentation profiles (a, left) and by the separation of the patient with colorectal cancer from the healthy samples (n = 25) in a principal component analysis (b).
