Extended Data Fig. 10: Structural MRI and seed-based functional MRI analysis of macaque brains.
From: Atypical behaviour and connectivity in SHANK3-mutant macaques
a–c, No difference in white matter volume (a) and cerebrospinal fluid volume (b), but a reduced volume of grey matter (c), in SHANK3 mutants, relative to control macaques. In a–c, n = 6 macaques for control group; n = 5 macaques for SHANK3-mutant group. Data are presented as mean ± s.e.m., **P < 0.01, Mann–Whitney U-test. Coloured squares indicate individual mutant macaques. d, e, Sagittal, coronal and axial views of averaged functional MRI image from six control macaques (d) and five SHANK3 mutants (e), using the putative posterior cingulate cortex as seed region. f, Sagittal, coronal and axial views of averaged functional MRI image show blood-oxygen-level-dependent signals in the posterior cingulate cortex that are greater in mutants than in controls. In d –f, the putative posterior cingulate cortex regions are highlighted by arrows.
