Extended Data Fig. 9: Characteristics of off-target RNA SNVs for engineered BE3 and ABE7.10 variants.
From: Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis
a, Schematic of BE3 and ABE7.10 variants. Point mutations are indicated by red lines. b, Representative distributions of off-target RNA SNVs on human chromosomes. c, Distribution of mutation types for each sample of the engineered variants of BE3 and ABE7.10. d, Ratio of shared RNA SNVs between any two samples in the engineered variants of BE3 and ABE7.10 or with off-target sites predicted by Cas-OFFinder. The proportion in each cell was calculated by the number of overlapping RNA SNVs between two samples divided by the number of RNA SNVs in the row.
