Extended Data Fig. 6: Cell-cycle module expression in mutant and wild-type progenitor cells.
From: Somatic mutations and cell identity linked by Genotyping of Transcriptomes
a, S-phase and G2- and M-phase gene-module expression in wild-type and mutant cells, in HSPC and MkP clusters from essential thrombocythaemia samples. Cell-cycle module score represents the sum of S-phase and G2- and M-phase gene-module expression (two-sided Wilcoxon rank-sum test; see Methods and Supplementary Table 6 for sample size). Analysis was performed for clusters with at least 20 cells. b, Ratio of committed-progenitor priming-module expression of mutant and wild-type HSPCs. One mutant and one wild-type HSPC were randomly sampled from samples ET01–ET05 for each round of analysis (n = 1,000 iterations, two-sided Wilcoxon rank-sum test).
