Extended Data Fig. 9: Old intestine recovers poorly from 5-FU-induced damage.
From: Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
a, Body weights of young and old mice following single injection of 5-FU (100–200 mg kg−1). Two mice per group, body weight relative to day of injection (day 0). b, Relative body weight of young and old mice treated for one week with or without ABC99 followed by single 5-FU (100 mg kg−1) injection (n = 8 mice for young vehicle, old vehicle and young ABC99-treated, n = 10 mice for old ABC99-treated). Daily data points represent median (circles) and interquartile range (dashed line). Daily weight of old ABC99-treated mice were compared to old controls with two-tailed unpaired Student’s t-test; exact P values shown under the corresponding daily weight. Young mice between 3 and 4 months of age; old mice over 20 months of age.
