Extended Data Fig. 12: Model for the evolution of the telencephalon.
From: Comprehensive single-cell transcriptome lineages of a proto-vertebrate
a, Gene-expression cascade of regulatory genes and signalling components of palp sensory cells (also known as axial columnar cells). Genes implicated in the development of the vertebrate telencephalon are labelled in red. b, Gene-expression cascade of regulatory genes and signalling components in the anterior-most regions of the sensory vesicle (Six3/6+ pro-anterior sensory vesicle). Genes implicated in vertebrate telencephalon development are labelled in blue. c, d, The putative regulatory interactions among transcription factors from the cascade of palp sensory cells (c) and Six3/6+ pro-anterior sensory vesicle (d) along their developmental trajectories. e, The FoxG reporter gene with Ciona enhancer sequence exhibits restricted expression in a subset of cells in the olfactory bulb of the killifish telencephalon (arrowheads) and in the eye lens (left, GFP channel; right, merged image of bright-field and GFP channel images). n = 3 independent transgenic lines (Methods). D, diencephalon; M, midbrain; T, telencephalon. Scale bar, 400 μm.
